Sepe holds doctoral degrees in both law and economics, from the Yale Law School and the Toulouse School of Economics, respectively. Before entering into academia, he practiced law at Clifford Chance in London and worked as an investment banker at Fortress Investment Group.
Sepe is professor of law and finance at the University of Arizona and the Institute for Advance Study in Toulouse – Toulouse School of Economics. He also taught at Northwestern University, the University of Chicago Law School, and the University of Pennsylvania Law School. His research examines questions in corporate law, contract theory, and financial regulation. His recent work focuses on theoretical and empirical corporate governance and, in particular, the division of power between boards and shareholders.